| Product Information | |
|---|---|
| Composition | Cefixime 50 mg |
| Dosage Form | Dry Syrup |
| Packing Size | 30 ml |
| Packing | HDPE Bottle with Water |
Sifan-50 is a high-quality pediatric antibiotic formulation containing Cefixime 50 mg per 5 ml of dry syrup, designed to combat a wide range of bacterial infections in children. Belonging to the third-generation cephalosporin class of antibiotics, Sifan-50 offers broad-spectrum activity against gram-positive and gram-negative bacteria. This dry syrup is formulated with child-friendly flavoring agents to ensure better palatability and adherence to treatment, making it a trusted solution for pediatric bacterial infections.
Cefixime, the active ingredient, is a semi-synthetic, beta-lactam antibiotic that works by inhibiting bacterial cell wall synthesis, effectively killing bacteria and preventing the spread of infection. The product is intended for pediatric use under a doctor’s prescription, offering accurate dosing for infants and young children through a reconstituted liquid suspension.
Each 5 ml of reconstituted suspension contains:
Cefixime IP 50 mg
Form: Dry syrup (to be reconstituted with water)
Type: Pediatric antibiotic
Broad-Spectrum Antibiotic: Effective against a wide variety of gram-positive and gram-negative bacteria.
Pediatric-Friendly Formulation: Specially designed for infants and children with a pleasant taste to encourage adherence.
Third-Generation Cephalosporin: Offers superior resistance against beta-lactamase-producing organisms, making it a strong choice for resistant bacterial strains.
Convenient Dosing: Supplied as a dry powder that is reconstituted into a liquid suspension, making administration easier for children.
Safe and Well-Tolerated: Suitable for pediatric use when prescribed by a healthcare professional.
Cefixime, a third-generation cephalosporin, is a bactericidal antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), preventing the formation of peptidoglycan, an essential component of bacterial cell walls. This leads to cell wall rupture and bacterial death.
Cefixime is stable against hydrolysis by many beta-lactamases, allowing it to work effectively against bacteria that produce these enzymes. Its broad coverage includes organisms such as:
Gram-negative bacteria: Escherichia coli, Klebsiella spp., Proteus spp., Haemophilus influenzae, Neisseria gonorrhoeae
Gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes
Sifan-50 is indicated for the treatment of pediatric bacterial infections caused by susceptible strains of microorganisms. Conditions include:
Upper Respiratory Tract Infections (URTIs)
Tonsillitis, Pharyngitis
Sinusitis
Lower Respiratory Tract Infections (LRTIs)
Bronchitis, Pneumonia
Ear, Nose, and Throat (ENT) Infections
Otitis Media
Urinary Tract Infections (UTIs)
Cystitis, Pyelonephritis
Gastrointestinal Infections
Typhoid fever, Gastroenteritis caused by Salmonella and Shigella species
Skin and Soft Tissue Infections
Gonorrhea (in pediatric/adolescent patients when prescribed by a doctor)
Dosage: As prescribed by a pediatrician, typically based on body weight (mg/kg).
Route: Oral
Preparation:
Shake the dry powder bottle to loosen contents.
Add boiled and cooled water up to the marked line on the bottle.
Shake vigorously until a uniform suspension forms.
Store the reconstituted suspension in a refrigerator and use within 7–14 days as per instructions.
Important: Always use the measuring spoon or dropper provided to ensure accurate dosing.
Absorption: Well absorbed orally; bioavailability ~40–50%.
Protein Binding: Approximately 65%.
Half-Life: 3–4 hours, allowing twice-daily dosing.
Metabolism and Excretion: Primarily excreted unchanged in urine; safe for most pediatric patients when dosed correctly.
Enhanced Spectrum of Activity: Cefixime offers reliable action against resistant strains.
Beta-Lactamase Resistance: Retains effectiveness where other beta-lactam antibiotics fail.
Convenient Pediatric Dosing: Accurate weight-based dosing for infants and children.
Pleasant Taste and Child Compliance: Flavored syrup improves adherence.
Flexible Administration: Can be taken with or without food.
Like all antibiotics, Cefixime may have some side effects, though most are mild and transient.
Gastrointestinal: Diarrhea, nausea, vomiting, abdominal pain
Hypersensitivity Reactions: Rash, itching, urticaria
Rare Effects:
Anaphylaxis (severe allergic reaction, very rare)
Pseudomembranous colitis
Hematologic changes (temporary changes in blood counts)
Known allergy to Cefixime or other cephalosporin antibiotics
History of hypersensitivity to penicillins (cross-reactivity possible)
Caution in patients with severe renal impairment
Pediatric Use: Strictly under medical supervision; dose adjusted according to body weight.
Renal Impairment: Dose adjustment may be necessary.
Antibiotic Stewardship: Should be used only for bacterial infections, not viral illnesses (e.g., colds or flu).
Reconstitution Instructions: Follow carefully to maintain potency.
Adherence: Complete the prescribed course to prevent antibiotic resistance.
Carbamazepine: Increased serum levels when combined.
Anticoagulants: Monitor INR with warfarin or other blood thinners.
Live Vaccines: Antibiotics may reduce the effectiveness of live bacterial vaccines (e.g., typhoid).
Store the dry powder in a cool, dry place away from direct sunlight.
After reconstitution, keep refrigerated (not frozen).
Discard any unused suspension after 7–14 days.
Clinically Proven Antibiotic: Cefixime is a well-established antibiotic trusted by pediatricians.
Reliable Quality: Manufactured under stringent quality control to ensure consistent potency.
Child-Friendly Formulation: Designed for easy administration and better acceptance.
Effective Against Resistant Bacteria: Suitable for infections where first-line antibiotics may fail.
Comprehensive Packaging: Comes with dosing aids and clear preparation instructions.
Administer at Regular Intervals: Ensure doses are evenly spaced for maximum effectiveness.
Don’t Skip or Stop Early: Completing the course prevents antibiotic resistance.
Watch for Allergies: If your child develops rashes, breathing difficulty, or swelling, seek medical help immediately.
Probiotics Support: Consider probiotics to prevent antibiotic-associated diarrhea.
Sifan-50 Dry Syrup is a powerful, safe, and effective pediatric antibiotic formulated with Cefixime 50 mg for the treatment of various bacterial infections. Its child-friendly flavor, broad-spectrum coverage, and resistance to beta-lactamase enzymes make it a go-to solution for pediatricians. Designed with precision dosing and high-quality manufacturing standards, Sifan-50 ensures both safety and efficacy in treating bacterial illnesses in children.
By choosing Sifan-50, healthcare providers and parents can be assured of reliable treatment outcomes, improved patient compliance, and faster recovery for children suffering from bacterial infections.
