PREGMAC M-75

Introduction

Pregmac M-75 is a clinically formulated medication designed to manage neuropathic pain and support nerve health. It contains two potent active ingredients: Pregabalin, a widely used anticonvulsant and neuropathic pain modulator, and Mecobalamin (Vitamin B12 in its active form), which plays a critical role in nerve repair and regeneration. Together, these two ingredients offer synergistic benefits for patients suffering from nerve pain caused by various conditions, including diabetes, spinal cord injuries, postherpetic neuralgia, and peripheral neuropathy.

This medication is formulated as a tablet to ensure precise dosing, convenience, and rapid therapeutic action. By addressing both pain symptoms and the underlying nerve damage, Pregmac M-75 provides comprehensive relief, improving the quality of life for patients dealing with chronic neuropathic conditions.

Key Ingredients & Their Roles

1. Pregabalin (75mg):
   Pregabalin is a structural analogue of the neurotransmitter gamma-aminobutyric acid (GABA), though it does not bind directly to GABA receptors. Instead, it works by modulating calcium channels in nerve cells, reducing the excessive release of neurotransmitters responsible for pain signaling.

   • Helps reduce abnormal electrical activity in the brain and spinal cord.

   • Effectively manages neuropathic pain caused by diabetes, shingles, or injuries.

   • Offers additional benefits in generalized anxiety disorder and fibromyalgia.

2. Mecobalamin (750mcg):
   Mecobalamin is an active coenzyme form of Vitamin B12 that plays a vital role in the synthesis of myelin, the protective sheath surrounding nerve fibers.

   • Supports nerve regeneration and repair.

   • Corrects Vitamin B12 deficiency-related neuropathy.

   • Helps in the production of neurotransmitters and red blood cells.

   • Enhances cognitive function and overall neurological health.

Mechanism of Action

Pregmac M-75 works on multiple levels:

• Pregabalin binds to alpha-2-delta subunits of calcium channels, reducing calcium influx into overactive nerve cells. This decreases the release of excitatory neurotransmitters like glutamate and substance P, which are responsible for nerve pain.

• Mecobalamin provides essential nutrition to damaged nerve cells, promotes axonal regeneration, and supports remyelination, restoring proper nerve signaling.
  The combination provides both symptomatic relief from neuropathic pain and long-term nerve health support.

Indications (Uses)

Pregmac M-75 is recommended for the treatment and management of:

• Diabetic peripheral neuropathy

• Postherpetic neuralgia (nerve pain after shingles)

• Fibromyalgia

• Sciatica and other chronic nerve compression syndromes

• Trigeminal neuralgia

• Neuropathic pain associated with spinal cord injuries

• Chemotherapy-induced peripheral neuropathy

• Vitamin B12 deficiency-related neurological disorders

• Generalized anxiety disorder (as adjunct therapy)

Benefits of Pregmac M-75

1. Comprehensive Neuropathic Pain Relief:
   By targeting both nerve hyperexcitability and nerve damage, Pregmac M-75 reduces burning, tingling, numbness, and shooting pain sensations.

2. Nerve Protection and Repair:
   Mecobalamin promotes nerve regeneration, which can lead to long-term improvement in nerve function.

3. Convenient Tablet Form:
   A single tablet offers precise dosing, improving adherence to therapy.

4. Dual Action Formula:
   While Pregabalin controls abnormal nerve signaling, Mecobalamin nourishes and restores nerve health.

5. Improved Quality of Life:
   Reducing chronic pain allows patients to regain mobility, sleep better, and manage daily tasks without discomfort.

Dosage and Administration

• Typical Dosage: One tablet once or twice daily, as prescribed by a healthcare provider.

• The dosage may vary depending on the severity of the condition, age, and patient response.

• It is important to take the tablet with or without food, at the same time each day, for best results.

How to Take Pregmac M-75 Safely

• Swallow the tablet whole with a glass of water.

• Do not crush, chew, or break the tablet.

• Take the medication consistently for maximum benefit, even if symptoms improve.

• If a dose is missed, take it as soon as you remember unless it is close to the next scheduled dose.

Side Effects

Most side effects are mild and temporary, but patients should be aware of them:

• Dizziness or lightheadedness

• Drowsiness or fatigue

• Dry mouth

• Weight gain (in prolonged use)

• Blurred vision

• Swelling in the hands or feet

• Mild gastrointestinal discomfort

If severe side effects like difficulty breathing, swelling of the face, or severe allergic reactions occur, seek immediate medical attention.

Precautions and Warnings

• Pregnancy & Breastfeeding: Consult a healthcare provider before use.

• Kidney Disorders: Pregabalin is excreted by the kidneys, so dosage adjustments may be necessary.

• Driving & Operating Machinery: The medication may cause dizziness; avoid driving if you feel drowsy.

• Alcohol Use: Avoid alcohol consumption as it may worsen dizziness and drowsiness.

• Other Medications: Inform your doctor about all ongoing medications, especially CNS depressants.

Drug Interactions

Pregmac M-75 may interact with:

• Opioid painkillers (increased risk of sedation)

• Sedatives and anti-anxiety drugs

• Antihistamines

• Alcohol
  Always consult a healthcare professional before combining medications.

Storage Instructions

• Store in a cool, dry place below 25°C.

• Keep away from direct sunlight and moisture.

• Keep out of reach of children.

Why Choose Pregmac M-75?

Pregmac M-75 is a well-researched, highly effective, and safe formulation designed to provide holistic care for neuropathic pain. Unlike single-drug treatments, its dual-action approach not only alleviates pain but also addresses nerve damage, ensuring better long-term outcomes. The combination of Pregabalin and Mecobalamin offers patients an opportunity to recover nerve health while enjoying pain relief, making it an essential choice for those dealing with chronic neurological conditions.

Conclusion

Neuropathic pain is a debilitating condition that affects millions worldwide, and managing it effectively requires both symptomatic relief and nerve repair. Pregmac M-75 offers a balanced, scientifically backed solution for this challenge. With its powerful combination of Pregabalin for nerve pain modulation and Mecobalamin for nerve restoration, this tablet provides relief, repair, and renewal for individuals suffering from neuropathic pain.

By following a healthcare provider’s guidance and maintaining a consistent treatment plan, Pregmac M-75 can significantly improve mobility, reduce discomfort, and enhance overall quality of life.