| Composition | Sucralfate 1gm Oxetacaine 20mg |
|---|---|
| Dosage | SUSPENSION |
| Packing Size | 100ml |
| Packing | Bottle with ctn |
AVESET-O is a specialized gastrointestinal formulation designed to provide dual therapeutic action for patients suffering from gastric and duodenal ulcers, gastritis, acid peptic disorders, and associated pain or discomfort. The unique combination of Sucralfate (1g) and Oxetacaine (20mg) makes AVESET-O an effective solution for managing both mucosal damage caused by excess gastric acid and the pain or burning sensation associated with ulcerative or inflammatory conditions of the gastrointestinal tract.
This product is generally available as an oral suspension or tablet and is widely prescribed by healthcare professionals to accelerate healing of gastric mucosa, protect the gastrointestinal lining, and provide long-lasting relief from acidity and related symptoms.
Sucralfate (1g)
Pharmacological Class: Gastroprotective agent / Cytoprotective drug
Mechanism of Action: Sucralfate acts locally in the stomach and duodenum to create a viscous protective barrier over the ulcer or inflamed mucosa. When exposed to acidic pH, Sucralfate undergoes polymerization and binds to proteins at ulcer sites, forming a physical protective coating. This barrier prevents damage from gastric acid, pepsin, and bile salts, promoting faster healing.
Key Benefits:
Protects ulcerated mucosa and prevents further injury.
Enhances healing of gastric and duodenal ulcers.
Increases local growth factors and prostaglandin secretion, improving mucosal defense.
Minimally absorbed, reducing systemic side effects.
Oxetacaine (20mg)
Pharmacological Class: Topical anesthetic and antacid agent
Mechanism of Action: Oxetacaine (also called Oxethazaine) is a potent local anesthetic with acid-neutralizing properties. It provides rapid relief from pain, burning sensation, and irritation associated with gastric hyperacidity and ulcers by numbing the mucosal nerve endings.
Key Benefits:
Immediate and sustained relief from epigastric pain and burning.
Reduces discomfort associated with reflux esophagitis, gastritis, and peptic ulcers.
Complements Sucralfate’s mucosal protective action.
AVESET-O is indicated for a wide range of acid-related gastrointestinal disorders, including:
Gastric and Duodenal Ulcers: For protecting and healing mucosal lesions caused by excessive acid secretion or H. pylori infection (as part of combination therapy).
Gastritis and Erosive Gastritis: Provides mucosal protection and pain relief.
Gastroesophageal Reflux Disease (GERD): Reduces acidity, pain, and esophageal irritation.
Acid Peptic Disorders: Offers symptomatic relief and mucosal healing.
Reflux Esophagitis: Prevents esophageal irritation caused by acidic reflux.
Burning Sensation and Pain in Upper GI Tract: Rapid symptomatic relief due to Oxetacaine.
Post-Endoscopic or Post-Surgical GI Mucosal Protection: Helps coat the mucosa and prevent further irritation.
This combination works in two synergistic ways:
Sucralfate’s Cytoprotective Barrier
Sucralfate selectively binds to damaged mucosal tissue, creating a viscous, sticky protective barrier at ulcer sites.
It acts as a mechanical shield against hydrochloric acid, pepsin, and bile salts, allowing the damaged tissue to heal.
It stimulates prostaglandin synthesis and epithelial growth, speeding up mucosal regeneration.
Oxetacaine’s Local Anesthetic and Acid-Neutralizing Effect
Oxetacaine provides fast, long-lasting anesthesia to mucosal surfaces, instantly reducing burning sensation and epigastric pain.
It helps neutralize stomach acid locally, reducing irritation.
Together, they deliver comprehensive relief: Sucralfate ensures ulcer healing, while Oxetacaine provides quick symptomatic relief, making AVESET-O a preferred prescription for patients with acute symptoms of acidity, ulcers, and reflux.
(To be taken only under medical supervision)
Typical Dosage:
Adults: Usually prescribed 1g Sucralfate + 20mg Oxetacaine formulation taken 2–4 times daily.
Best taken on an empty stomach (at least 1 hour before meals and at bedtime).
Form: Oral suspension or tablet. The suspension should be shaken well before use.
Duration: Usually continued for 4–8 weeks depending on the severity of ulcers or gastritis.
Special Instructions:
Avoid taking antacids or other medications immediately after AVESET-O; a 30–60 minute gap is recommended.
Should be used consistently for maximum mucosal protection.
Dual Action Therapy – Heals ulcers and relieves pain simultaneously.
Fast-Acting Symptom Relief – Oxetacaine provides rapid relief from burning sensation.
Long-Lasting Protection – Sucralfate’s barrier effect protects mucosa for hours.
Minimally Systemic – Sucralfate acts locally with negligible systemic absorption, reducing adverse effects.
Ideal for Severe Cases – Provides strong protection in severe acidity, GERD, or chronic ulcer cases.
Sucralfate:
Acts locally in the GI tract with negligible absorption.
Eliminated via feces, making it safe for long-term use.
Oxetacaine:
Poorly absorbed systemically, acts locally for prolonged periods.
This pharmacokinetic profile ensures maximum local effectiveness with minimal systemic toxicity.
Pregnancy & Lactation: Use only if prescribed by a doctor.
Kidney Impairment: Monitor for aluminum accumulation in patients with renal disease.
Drug Interactions: May interfere with absorption of certain drugs (e.g., tetracyclines, digoxin); maintain dosing intervals.
Not for Immediate Acid Neutralization: While Oxetacaine has local anesthetic and acid-suppressing properties, this formulation is not a substitute for systemic antacids or PPIs in severe GERD.
Children: Use only under strict medical advice.
Generally well-tolerated due to minimal absorption. Mild side effects may include:
Constipation (due to Sucralfate’s aluminum content)
Dry mouth
Nausea or indigestion
Rare allergic reactions
Store in a cool, dry place, away from direct sunlight.
Keep the bottle tightly closed.
Do not refrigerate unless specified.
Keep out of reach of children.
AVESET-O offers comprehensive gastrointestinal care by combining Sucralfate’s proven ulcer-healing properties with Oxetacaine’s rapid pain relief. Unlike single-agent treatments, this dual-action medication simultaneously heals, protects, and soothes the stomach lining, making it ideal for patients suffering from:
Persistent heartburn
Painful gastritis
Recurrent peptic ulcers
Chronic acid reflux disorders
Its ability to provide both immediate relief and long-term healing makes it a highly effective and preferred choice among physicians for managing acid-related disorders.
AVESET-O (Sucralfate 1g + Oxetacaine 20mg) is a trusted gastrointestinal formulation that offers maximum mucosal protection and symptom control. By leveraging the cytoprotective power of Sucralfate and the anesthetic effect of Oxetacaine, it provides patients with fast, safe, and effective treatment for ulcers, gastritis, GERD, and other acid-related gastrointestinal conditions. Its localized action, minimal side effects, and long-lasting efficacy make it a go-to therapy for healthcare professionals seeking both symptomatic and structural healing of the gastrointestinal tract.
