GLICAFINE 60

GLICAFINE 60

Description:

GLICAFINE 60 is an oral antidiabetic medication formulated with Gliclazide 60 mg, a second-generation sulfonylurea class drug. It is designed to help manage Type 2 Diabetes Mellitus (T2DM) in patients whose blood sugar levels are not adequately controlled through diet, exercise, and lifestyle modifications alone. By improving insulin secretion from the pancreas, GLICAFINE 60 aids in reducing blood glucose levels and helps prevent the long-term complications associated with diabetes.

Mechanism of Action:

Gliclazide stimulates the pancreatic beta cells to release insulin, improving glycemic control. It enhances both the first and second phases of insulin secretion in response to glucose intake. Additionally, Gliclazide has beneficial effects on microcirculation due to its antioxidant properties, which may reduce the risk of diabetic complications like retinopathy and nephropathy.

Indications:

GLICAFINE 60 is indicated for:

• Management of Type 2 Diabetes Mellitus in adults.

• Patients whose blood sugar levels are not adequately controlled by diet and exercise.

• Monotherapy or combination therapy with other oral antidiabetic agents (like Metformin).

Key Benefits:

• Provides effective blood glucose control by increasing natural insulin production.

• Reduces the risk of microvascular complications due to diabetes.

• Can be taken once daily due to its modified-release formulation, improving compliance.

• Has a lower risk of severe hypoglycemia compared to older sulfonylureas.

Dosage and Administration:

• Recommended starting dose: 30 mg once daily with breakfast.

• Maintenance dose: May be increased to 60 mg once daily, based on blood sugar levels and individual response.

• Dose adjustments should be made gradually under medical supervision.

• Tablets should be swallowed whole and not crushed or chewed.

Side Effects:

Some common side effects may include:

• Mild hypoglycemia (low blood sugar)

• Dizziness or headache

• Gastrointestinal discomfort (nausea, stomach pain)

• Skin rash or allergic reactions (rare)

Precautions:

• Not recommended for Type 1 Diabetes or diabetic ketoacidosis.

• Use with caution in patients with renal or hepatic impairment.

• Regular monitoring of blood glucose levels is essential.

• Should be taken with a balanced diet and regular exercise for best results.

Drug Interactions:

GLICAFINE 60 may interact with:

• Other antidiabetic agents (e.g., insulin, Metformin)

• Beta-blockers, corticosteroids, diuretics, and anticoagulants

• Alcohol (may increase hypoglycemia risk)

Storage:

• Store in a cool, dry place away from direct sunlight.

• Keep out of reach of children.

Conclusion:

GLICAFINE 60 is a trusted solution for effective blood sugar control in Type 2 Diabetic patients. Its once-daily modified-release formulation ensures convenience, better adherence, and improved glycemic stability, making it a preferred choice for long-term diabetes management under medical supervision.