| Composition | Levosulpiride 25mg |
|---|---|
| Dosage | TABLET |
| Packing Size | 6x5x10 |
| Packing | Blister |
Levisil 25 is a highly effective prokinetic and antipsychotic medication formulated with Levosulpiride 25mg as its active ingredient. Belonging to the benzamide class of drugs, Levosulpiride is a selective dopamine D2 receptor antagonist, widely recognized for its dual benefits in gastrointestinal (GI) motility disorders and certain psychiatric conditions. This medication is designed to deliver consistent therapeutic outcomes through precise dosing, ensuring both efficacy and safety for patients.
Active Ingredient: Levosulpiride 25 mg
Dosage Form: Tablet
Pharmacological Class: Atypical antipsychotic and prokinetic
Mechanism of Action: Selective dopamine D2 receptor antagonist
Levosulpiride works by blocking presynaptic and central dopamine D2 receptors. By doing so, it enhances dopaminergic transmission in the frontal cortex and regulates serotonergic activity, which helps in managing psychiatric symptoms like depression, schizophrenia, and anxiety. Additionally, Levosulpiride exerts a prokinetic effect on the GI tract by promoting acetylcholine release in the enteric nervous system. This leads to increased gastric emptying and intestinal motility, making it highly beneficial for functional dyspepsia, gastroesophageal reflux disease (GERD), and other GI motility disorders.
Levisil 25 is a versatile medication used across multiple medical specialties due to its broad pharmacological profile. Key therapeutic areas include:
Gastroenterology Applications:
Functional dyspepsia and bloating
Gastroesophageal reflux disease (GERD)
Gastroparesis
Chronic constipation associated with poor gut motility
Nausea and vomiting due to delayed gastric emptying
Irritable bowel syndrome (IBS) with motility disturbances
Psychiatry Applications:
Treatment of schizophrenia, particularly negative symptoms
Depression associated with psychomotor retardation
Somatoform disorders with GI complaints
Anxiety disorders
Dysthymia and mild mood disorders
Other Indications:
Adjunct therapy for vertigo
Management of Parkinsonism-related GI symptoms
Relief of psychosomatic symptoms linked to digestive issues
Levosulpiride’s mechanism of action is unique because it selectively inhibits dopamine D2 receptors while sparing D1 receptors. Unlike traditional antipsychotics, which cause excessive sedation and extrapyramidal side effects, Levosulpiride’s selective nature provides a better safety profile.
In the GI tract, blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) prevents nausea and vomiting. Additionally, dopamine typically slows gut motility; by blocking dopamine, Levosulpiride enhances gastric emptying and intestinal peristalsis. This dual action of regulating both central and peripheral dopamine activity makes it a unique therapeutic agent.
Absorption: Levosulpiride is rapidly absorbed when administered orally, with high bioavailability.
Distribution: It distributes extensively into body tissues, particularly the central nervous system (CNS) and gastrointestinal tract.
Metabolism: Minimal hepatic metabolism; largely excreted unchanged.
Elimination Half-life: Approximately 6–8 hours.
Excretion: Primarily excreted in urine, ensuring predictable plasma levels.
The standard dosage for Levisil 25 may vary based on the indication:
For GI motility disorders: 25 mg two to three times daily before meals.
For psychiatric disorders: Dosages may be gradually increased under medical supervision, depending on patient response.
Route of Administration: Oral
The medication should be used strictly under medical guidance to avoid side effects and ensure therapeutic efficacy.
Dual Benefit: Acts as both an antipsychotic and prokinetic agent, addressing multiple conditions simultaneously.
High Selectivity: Selective dopamine D2 receptor antagonism reduces the risk of extrapyramidal side effects (EPS) seen with older antipsychotics.
Gastrointestinal Relief: Rapidly improves symptoms of delayed gastric emptying, bloating, reflux, and nausea.
Better Tolerability: Minimal sedative effects, making it well-tolerated even for long-term use.
Reliable Pharmacokinetics: High bioavailability and predictable plasma levels ensure consistent therapeutic outcomes.
While Levisil 25 is generally safe, prolonged or high-dose therapy may result in side effects:
Neurological: Rare cases of extrapyramidal symptoms, tremors, or mild akathisia.
Endocrine: Hyperprolactinemia leading to galactorrhea or menstrual irregularities in women.
Gastrointestinal: Mild constipation, diarrhea, or abdominal discomfort.
Other: Fatigue, dizziness, or mild sedation in some patients.
Precautions:
Avoid in patients with pheochromocytoma or epilepsy.
Use cautiously in renal impairment, adjusting the dosage accordingly.
Avoid concurrent alcohol or sedative medications to minimize CNS depression.
Levisil 25 may interact with:
CNS depressants: Enhanced sedation when combined with benzodiazepines or alcohol.
Antihypertensives: Possible additive hypotensive effect.
Levodopa: Antagonizes levodopa’s efficacy, hence should be avoided in Parkinson’s patients.
Patients using Levisil 25 should be informed about:
Taking medication before meals to maximize GI motility benefits.
Reporting any neurological or hormonal side effects early.
Avoiding alcohol consumption during therapy.
Adherence to prescribed dosage, as abrupt discontinuation can worsen symptoms.
Levisil 25 (Levosulpiride 25mg) is a highly reliable choice for patients experiencing digestive disorders linked to motility dysfunction as well as those with mild psychiatric or psychosomatic conditions. Its unique pharmacological profile allows it to restore gastrointestinal function while simultaneously improving mood and reducing anxiety. For physicians, it provides a versatile therapeutic option that is well-tolerated, safe, and backed by extensive clinical evidence.
Levosulpiride is widely prescribed by gastroenterologists, psychiatrists, and internists due to its broad therapeutic spectrum. In an era where gastrointestinal and mental health issues often coexist, medications like Levisil 25 provide a comprehensive solution. Clinical studies confirm its efficacy in treating functional dyspepsia, GERD, IBS, and mood disorders, making it a valuable addition to any therapeutic regimen.
Levisil 25 is a clinically proven, well-formulated medication containing Levosulpiride 25mg that addresses both gastrointestinal motility disorders and psychiatric conditions effectively. With its selective dopamine D2 antagonism, it offers improved GI motility, enhanced gastric emptying, and relief from psychosomatic symptoms, all while maintaining a favorable safety profile. Its versatility, efficacy, and tolerability make it a preferred choice among healthcare professionals for patients requiring dual-action therapy.
