| Product Information | |
|---|---|
| Composition | Mebeverine Hydrochloride 200 mg |
| Dosage Form | Tablet |
| Packing Size | 10 x 10 |
| Packing | Blister |
Mebesin-200 PR is a prolonged-release (PR) capsule formulation containing Mebeverine Hydrochloride 200mg, a well-known antispasmodic medication primarily prescribed for the management of Irritable Bowel Syndrome (IBS) and various gastrointestinal (GI) conditions characterized by abdominal cramping, bloating, and discomfort. This medicine works by relaxing the smooth muscles of the gastrointestinal tract without affecting normal gut motility, making it a preferred choice for patients with IBS, colitis, and other functional bowel disorders.
Active Ingredient:
Mebeverine Hydrochloride 200mg (Prolonged-Release Formulation)
Dosage Form: Prolonged-release capsules
Strength: 200mg
Route of Administration: Oral
Packaging: Typically available in blister strips or bottles
The prolonged-release (PR) formulation ensures sustained drug release
over time, allowing for twice-daily dosing and improved compliance for patients with chronic digestive disorders.
Therapeutic Class: Antispasmodic/Anticholinergic substitute
Pharmacological Class: Musculotropic antispasmodic agent
Mode of Action: Direct smooth muscle relaxant (non-anticholinergic)
Mebeverine Hydrochloride acts directly on the smooth muscles of the gastrointestinal tract, particularly the colon and small intestine. Unlike conventional anticholinergics, it does not block muscarinic receptors, thus avoiding systemic anticholinergic side effects such as dry mouth, blurred vision, or urinary retention.
Key action points:
Smooth Muscle Relaxation:
Mebeverine reduces muscle contractions and spasms in the intestinal wall, thereby alleviating cramping and abdominal pain.
Normalization of Gut Motility:
It helps restore rhythmic peristaltic movement of the gut, easing irregular bowel habits without causing constipation or diarrhea.
No Anticholinergic Effect:
Since it does not interfere with cholinergic activity, it is safer for elderly patients and those with cardiovascular conditions.
Absorption: Well absorbed in the gastrointestinal tract.
Onset of Action: Rapid, with symptom relief within a few hours.
Half-life: Approximately 2–5 hours (due to PR formulation, drug release is sustained).
Metabolism: Undergoes hepatic metabolism into inactive metabolites.
Excretion: Eliminated via urine as metabolites.
Mebesin-200 PR is widely prescribed for functional gastrointestinal disorders:
Irritable Bowel Syndrome (IBS):
Helps relieve abdominal cramping, bloating, and discomfort associated with IBS.
Reduces urgency and irregular bowel movements.
Spastic Colon & Functional Colitis:
Relieves colonic muscle spasms without disturbing normal gut movement.
Chronic Irritable Bowel Conditions:
Useful in chronic idiopathic bowel syndrome.
Diverticular Disease:
Eases colonic pain and discomfort in diverticular disease patients.
Non-ulcer Dyspepsia:
Reduces pain and bloating in patients with functional dyspepsia.
Post-Operative or Post-Inflammatory GI Spasm:
Can be used to manage intestinal spasms after surgeries or inflammatory bowel episodes.
Recommended Dose:
One capsule of Mebesin-200 PR (200mg) twice daily.
Route: Oral
Timing: Should be taken 20 minutes before meals with water.
Duration: Depends on clinical response; may be used long-term under medical supervision.
Steady Drug Release: Maintains stable blood concentration for longer periods.
Convenient Dosing: Twice-daily dosing improves compliance.
Reduced Side Effects: Lower peak plasma concentration minimizes adverse effects.
Effective Symptom Control: Provides day-long relief from IBS symptoms.
Mebeverine is generally well tolerated, but some patients may experience:
Mild dizziness or headache
Skin rash or urticaria (rare allergic reactions)
Nausea or mild stomach upset
Rare cases of angioedema or hypersensitivity
Most adverse reactions are mild and resolve without discontinuation of therapy.
Hypersensitivity to Mebeverine or formulation excipients
Paralytic ileus or gut obstruction
Severe hepatic or renal impairment (caution required)
Not recommended for children under 12 years
Mebeverine is metabolized extensively, but no clinically significant drug interactions have been reported.
Can be safely co-administered with antacids, antidiarrheal agents, and probiotics.
Should be used with caution in patients with hepatic or renal insufficiency.
Pregnant or lactating women should only use under medical guidance.
Elderly patients can use safely due to minimal anticholinergic effects.
Targeted Relief for IBS: Provides symptom relief without altering gut microbiota.
Better Tolerability: No sedation or systemic side effects.
Improved Quality of Life: Reduces discomfort, improves appetite, and aids digestion.
Minimal Drug Interactions: Safe for polypharmacy patients.
| Feature | Mebeverine (Mebesin-200 PR) | Anticholinergics | Other Spasmolytics |
|---|---|---|---|
| Mode of Action | Direct smooth muscle relaxant | Muscarinic receptor blocker | Mixed |
| Side Effects | Minimal | Dry mouth, blurred vision, urinary retention | Moderate |
| Effectiveness | High in IBS & spastic bowel | Moderate | Variable |
| Safety in Elderly | Safe | Less safe | Varies |
Mebeverine stands out for high tolerability and effectiveness in functional bowel disorders.
Store in a cool, dry place below 25°C.
Keep away from direct sunlight and moisture.
Keep out of reach of children.
Take the capsule whole; do not crush or chew.
For best results, maintain regular dosing schedule.
Continue dietary modifications: high-fiber diet, hydration, and exercise.
Report any signs of allergic reactions immediately.
Long-term use is safe, but follow-up visits are recommended.
Mebesin-200 PR containing Mebeverine Hydrochloride 200mg is a clinically proven, well-tolerated antispasmodic that provides lasting relief for patients suffering from IBS and functional bowel disorders. Its prolonged-release formulation offers superior symptom management, better compliance, and minimal side effects compared to other spasmolytic agents. With its targeted mechanism of action, Mebesin-200 PR is a trusted choice for gastroenterologists and a lifeline for patients seeking long-term relief from gastrointestinal discomfort.
