| Product Information | |
|---|---|
| Composition | Pantoprazole 40 mg |
| Dosage Form | VIAL |
| Packing Size | 40 mg |
| Packing | Vial with WFI |
Pantocop 40 is a highly effective proton pump inhibitor (PPI) designed to treat and manage various gastrointestinal (GI) conditions caused by excessive acid production in the stomach. Each tablet contains Pantoprazole 40 mg, a potent medication that provides long-lasting relief from acid-related discomforts such as heartburn, gastroesophageal reflux disease (GERD), peptic ulcers, and erosive esophagitis. By reducing stomach acid secretion, Pantocop 40 promotes healing of damaged tissues in the digestive tract, prevents recurrence of acid-induced complications, and enhances overall digestive health.
Pantoprazole is a substituted benzimidazole derivative that acts specifically on the proton pumps in the stomach lining. It selectively inhibits the H+/K+ ATPase enzyme system, which is responsible for acid secretion, thus ensuring effective and prolonged suppression of gastric acid levels. This targeted mechanism of action makes Pantocop 40 one of the most widely prescribed and well-tolerated PPIs globally, suitable for both short-term and long-term therapy under medical supervision.
Active Ingredient: Pantoprazole Sodium Sesquihydrate equivalent to Pantoprazole 40 mg per tablet.
Dosage Form: Tablet (film-coated, enteric-coated to ensure drug release in the intestine and not in the stomach).
Therapeutic Class: Proton Pump Inhibitor (PPI).
Pantoprazole works by irreversibly binding to and inhibiting the H+/K+ ATPase pump located in the parietal cells of the stomach lining. These pumps are responsible for releasing hydrogen ions (acid) into the stomach. By blocking this final step in the acid production pathway, Pantoprazole significantly reduces gastric acidity.
Onset of Action: Within 2 to 3 hours of administration.
Duration of Action: Up to 24 hours after a single dose, providing sustained relief.
Unique Feature: Pantoprazole is highly selective, affecting only active proton pumps, which minimizes unwanted systemic effects.
Pantocop 40 is recommended for the prevention, treatment, and long-term management of the following conditions:
Gastroesophageal Reflux Disease (GERD): Chronic acid reflux leading to heartburn and esophageal irritation.
Erosive Esophagitis: Inflammation and damage of the esophagus due to acid exposure.
Peptic and Duodenal Ulcers: Promotes ulcer healing and prevents recurrence.
Zollinger–Ellison Syndrome: A rare condition with excessive gastric acid secretion caused by tumors.
NSAID-Associated Gastric Ulcers: Helps reduce gastric complications in patients on long-term NSAIDs.
Acid-Related Dyspepsia: Relief from indigestion caused by hyperacidity.
Helicobacter pylori Eradication Therapy: Used in combination with antibiotics to eradicate H. pylori, a common ulcer-causing bacterium.
Absorption: Pantoprazole is absorbed rapidly in the intestine, reaching peak plasma levels in about 2.5 hours.
Bioavailability: Approximately 77%, unaffected by food, though best taken on an empty stomach for optimal effect.
Metabolism: Extensively metabolized in the liver via the CYP2C19 enzyme pathway.
Elimination: Excreted primarily in urine (about 80%) and feces (about 20%).
Half-Life: Around 1 hour, but acid suppression lasts much longer due to irreversible proton pump inhibition.
Usual Adult Dose: One tablet of Pantocop 40 once daily, preferably in the morning.
Mode of Administration: Swallow whole with water; do not chew or crush the tablet as it is enteric-coated.
Treatment Duration: Typically 4–8 weeks for GERD and ulcers; may be extended or used as maintenance therapy in chronic conditions.
Special Populations:
Elderly: No dosage adjustment required.
Renal Impairment: No dose adjustment needed.
Hepatic Impairment: Dose adjustment or careful monitoring may be required.
Effective Acid Suppression: Long-lasting acid reduction ensures symptom relief and promotes mucosal healing.
Convenient Once-Daily Dosing: Simplifies treatment adherence for patients.
Enteric-Coated Tablet: Prevents premature drug degradation in the stomach and ensures delivery in the intestine.
Broad Clinical Application: Suitable for GERD, ulcers, and hypersecretory conditions.
Improves Quality of Life: Provides lasting relief from heartburn, indigestion, and acid reflux, allowing patients to lead more comfortable lives.
Pantocop 40 is generally well tolerated, but like all medications, it may cause some side effects in a few patients:
Common: Headache, nausea, diarrhea, flatulence, dizziness.
Less Common: Abdominal pain, vomiting, joint pain, rash.
Rare but Serious:
Vitamin B12 deficiency with prolonged use.
Low magnesium levels (hypomagnesemia).
Increased risk of bone fractures in long-term therapy.
Clostridium difficile-associated diarrhea (rare).
Patients are advised to report any unusual or persistent side effects to their healthcare provider.
Long-Term Use: Should be monitored due to potential risks of osteoporosis, vitamin/mineral deficiencies, and gastric infections.
Pregnancy and Breastfeeding: Use only if prescribed by a healthcare provider after risk assessment.
Liver Disorders: Dose adjustment may be necessary.
Drug Interactions:
May reduce absorption of drugs requiring acidic gastric pH (e.g., ketoconazole, itraconazole).
Interacts with anticoagulants like warfarin; monitoring is essential.
Minimal interaction with CYP enzymes compared to other PPIs, making it safer for polypharmacy patients.
Store below 25°C, protected from moisture and direct sunlight.
Keep out of reach of children.
Pantocop 40 stands out as a reliable and trusted medication for acid-related gastrointestinal disorders due to:
High Efficacy: Clinically proven to heal esophageal and gastric mucosal damage.
Fast Symptom Relief: Starts working within hours and maintains a 24-hour acid suppression.
Safety Profile: Well tolerated, even in elderly and multi-drug therapy patients.
Global Acceptance: Pantoprazole is widely recommended in international treatment guidelines for GERD and peptic ulcer management.
Pantocop 40 (Pantoprazole 40 mg) is a specialized proton pump inhibitor that plays a critical role in managing and treating a variety of acid-related conditions. By selectively and irreversibly blocking acid production at its source, it provides consistent relief from heartburn, reflux, and gastric irritation. Its enteric-coated formulation ensures optimal absorption, while its excellent safety profile makes it suitable for both short-term symptom relief and long-term maintenance therapy.
Whether for patients suffering from occasional acidity, chronic GERD, or those requiring protection from NSAID-induced ulcers, Pantocop 40 offers reliable, evidence-based therapy that improves digestive health and enhances quality of life.
