| Product Information | |
|---|---|
| Composition | S(-)Amlodipine 5 mg |
| Dosage Form | Tablet |
| Packing Size | 6 x 5 x 10 |
| Packing | Blister |
S AMINE 5 is a premium pharmaceutical formulation containing S(-)Amlodipine 5mg, a highly effective third-generation calcium channel blocker (CCB) designed to manage hypertension (high blood pressure) and angina (chest pain due to heart disease). S(-)Amlodipine, also known as Levo-Amlodipine, is the pharmacologically active enantiomer of amlodipine, meaning it is a more potent and selective molecule with better efficacy and fewer side effects compared to traditional racemic amlodipine.
This advanced formulation provides reliable blood pressure control, reduces cardiovascular risks, and enhances overall patient compliance due to its once-daily dosing. By improving vascular relaxation and lowering systemic resistance, S AMINE 5 helps prevent serious cardiovascular complications such as stroke, myocardial infarction (heart attack), and kidney damage.
S(-)Amlodipine Besylate 5mg (Active Enantiomer of Amlodipine)
S(-)Amlodipine is considered a superior choice over conventional amlodipine because it requires a lower dose for similar or better results, leading to minimal peripheral edema (swelling), improved tolerability, and enhanced blood pressure reduction.
S(-)Amlodipine belongs to the class of Dihydropyridine Calcium Channel Blockers (CCBs). It works by:
Blocking L-type calcium channels in vascular smooth muscle, preventing calcium influx.
Relaxing blood vessels (vasodilation), thereby reducing systemic vascular resistance.
Lowering blood pressure and decreasing the workload on the heart.
Increasing blood and oxygen supply to the heart muscle, effectively managing angina symptoms.
Due to its enantiomeric purity, S(-)Amlodipine achieves potent antihypertensive effects at half the conventional dose of racemic amlodipine, reducing dose-related adverse effects.
S AMINE 5 is prescribed in the following conditions:
Hypertension (Primary and Secondary)
For effective and sustained reduction of blood pressure.
Reduces the risk of cardiovascular complications like stroke and kidney failure.
Stable Angina and Vasospastic Angina (Prinzmetal’s Angina)
Improves coronary artery blood flow and oxygen delivery to the heart muscle.
Reduces frequency and severity of angina attacks.
Cardiovascular Risk Reduction
Recommended for patients with multiple risk factors, such as diabetes, obesity, smoking, and high cholesterol.
Hypertensive Patients with Comorbidities
Beneficial in elderly patients and those with kidney disease due to its renal-protective effects.
Better Tolerability: Less risk of ankle swelling and peripheral edema.
Potent Blood Pressure Control: Greater antihypertensive effect at half the dose.
Improved Safety Profile: Reduces dose-related adverse effects like palpitations and flushing.
Once-Daily Dosing: Long half-life ensures 24-hour blood pressure control.
Renal and Cardiovascular Protection: Helps reduce end-organ damage in hypertensive patients.
Recommended Dose: One tablet of S AMINE 5 once daily, preferably at the same time each day.
The dose may be adjusted based on clinical response.
Can be used as monotherapy or in combination with other antihypertensives like beta-blockers, ARBs, ACE inhibitors, or diuretics.
Route of Administration: Oral.
Absorption: Excellent oral bioavailability (~80–90%).
Onset of Action: Gradual, with peak plasma concentration in 6–12 hours.
Half-Life: ~35–50 hours, allowing once-daily dosing.
Metabolism: Extensively metabolized in the liver via CYP3A4.
Excretion: Eliminated primarily in urine as inactive metabolites.
Superior Enantiomeric Purity: Contains only the active enantiomer for targeted action.
Enhanced Patient Compliance: Lower incidence of adverse effects means better adherence.
Clinically Proven Efficacy: Multiple studies demonstrate its superior blood pressure control compared to conventional formulations.
Safe for Long-Term Therapy: Ideal for chronic hypertension and angina management.
Cost-Effective: High-quality formulation offering significant clinical benefits at an affordable price.
S AMINE 5 is well-tolerated by most patients, but some may experience:
Mild headache
Dizziness or fatigue
Flushing (rare)
Peripheral edema (much lower than racemic amlodipine)
Mild gastrointestinal disturbances
Serious side effects are rare but should be reported immediately, such as:
Severe hypotension
Chest pain or palpitations
Allergic reactions (rash, itching, swelling)
Avoid S AMINE 5 in patients with:
Severe hypotension (low blood pressure)
Cardiogenic shock
Known hypersensitivity to amlodipine or other dihydropyridines
Advanced heart failure (requires close monitoring)
Use cautiously in hepatic impairment due to hepatic metabolism.
Not recommended for pregnant or breastfeeding women unless prescribed by a physician.
Should not be stopped suddenly; tapering may be required to prevent rebound hypertension.
Antihypertensives: May potentiate blood pressure-lowering effects.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin): May increase amlodipine levels.
CYP3A4 Inducers (e.g., rifampicin, carbamazepine): May reduce efficacy.
Grapefruit Juice: May enhance amlodipine concentration and effects.
The development of S(-)Amlodipine highlights the pharmaceutical industry’s move toward chiral switching—using only the active enantiomer of a racemic drug. This leads to:
Reduced side effects
Better pharmacodynamic properties
Improved safety and efficacy for long-term use
Store in a cool, dry place below 25°C.
Keep away from direct sunlight and moisture.
Keep out of reach of children.
Take S AMINE 5 at the same time daily to maintain steady blood levels.
Do not skip doses or stop medication without consulting a doctor.
Regularly monitor blood pressure and cholesterol levels.
Follow a low-sodium, heart-healthy diet.
Engage in regular exercise and weight management.
Limit alcohol and avoid smoking.
S AMINE 5, powered by S(-)Amlodipine 5mg, is a next-generation antihypertensive that delivers enhanced cardiovascular protection with improved tolerability. Its superior pharmacological profile makes it ideal for patients requiring long-term blood pressure and angina management. By combining advanced science with patient-centric benefits, S AMINE 5 stands out as a safe, effective, and innovative therapy for hypertension and cardiovascular risk reduction.
This formulation represents the future of cardiovascular medicine, offering precision therapy through enantiomeric purity.
