SIFAN-O

Sifan-O 

Sifan-O Tablet is a powerful broad-spectrum antibiotic combination of Cefixime (200 mg) and Ofloxacin (200 mg), specially formulated to treat a wide range of bacterial infections with high efficacy. This dual-action therapy combines the strengths of a third-generation cephalosporin antibiotic (Cefixime) and a fluoroquinolone antibiotic (Ofloxacin), making it highly effective against both gram-positive and gram-negative bacterial strains.

Designed for oral administration, Sifan-O Tablets are recommended for respiratory, urinary, gastrointestinal, skin, and soft tissue infections, as well as typhoid fever and other severe bacterial conditions. The combination ensures a synergistic antibacterial effect, rapid symptom relief, and reduced risk of resistance development, making it a trusted choice for healthcare professionals.

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Key Ingredients and Their Role

1. Cefixime (200 mg)

Cefixime is a third-generation cephalosporin antibiotic with a broad spectrum of activity. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death. It is effective against many beta-lactamase-producing bacteria, making it a reliable antibiotic for infections caused by resistant strains.

Key attributes of Cefixime:

• Highly effective against Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, and Escherichia coli.

• Offers excellent oral bioavailability.

• Provides prolonged antibacterial action due to its longer half-life.

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2. Ofloxacin (200 mg)

Ofloxacin is a fluoroquinolone antibiotic known for its potency and rapid action. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and cell division. By targeting these essential enzymes, Ofloxacin effectively halts bacterial multiplication.

Key attributes of Ofloxacin:

• Effective against multi-drug-resistant bacteria.

• Active against gram-negative and gram-positive bacteria, including atypical pathogens.

• Excellent penetration into body tissues and fluids for comprehensive infection control.

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Therapeutic Indications

Sifan-O Tablets are indicated for the treatment of a wide spectrum of bacterial infections, including:

1. Respiratory Tract Infections

   • Bronchitis, pneumonia, pharyngitis, tonsillitis, sinusitis.

2. Urinary Tract Infections (UTIs)

   • Cystitis, pyelonephritis, and complicated urinary tract infections.

3. Typhoid Fever and Enteric Fever

   • Effective in treating Salmonella Typhi and other enteric pathogens.

4. Gastrointestinal Infections

   • Bacterial diarrhea, dysentery, and infections caused by E. coli or Shigella.

5. Skin and Soft Tissue Infections

   • Cellulitis, abscesses, wound infections, and boils.

6. Bone and Joint Infections

   • Osteomyelitis, septic arthritis, and post-operative infections.

7. Ear, Nose, and Throat (ENT) Infections

   • Otitis media, sinusitis, and other ENT bacterial infections.

8. Sexually Transmitted Infections (STIs)

   • Gonorrhea and other infections caused by Neisseria gonorrhoeae.

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Mechanism of Action

The combination of Cefixime and Ofloxacin delivers a dual antibacterial mechanism:

1. Cefixime interferes with cell wall synthesis, weakening the bacterial cell structure and causing cell death.

2. Ofloxacin inhibits DNA replication enzymes (DNA gyrase and topoisomerase IV), halting bacterial division.

This dual action ensures synergistic efficacy and makes Sifan-O effective against even resistant bacterial strains.

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Key Benefits of Sifan-O Tablet

1. Broad-Spectrum Coverage:
   Targets a wide range of gram-positive and gram-negative bacteria, making it ideal for multiple infections.

2. Dual Antibiotic Therapy:
   Combines two powerful antibiotics for improved efficacy and lower resistance risk.

3. Fast-Acting Formula:
   Rapidly penetrates tissues and starts acting quickly to provide symptom relief.

4. Convenient Oral Tablet Form:
   Easy to administer with precise dosage, ensuring patient compliance.

5. Effective Against Resistant Bacteria:
   Cefixime’s stability against beta-lactamase and Ofloxacin’s potency provide an edge over resistant strains.

6. Trusted by Physicians:
   Widely recommended for both outpatient and inpatient bacterial infections.

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Dosage and Administration

• Recommended Dose:
  The dosage should be prescribed by a healthcare professional based on the severity of infection, patient’s weight, age, and overall health condition.

• General Adult Dose:
  Typically, one tablet twice daily or as directed by the physician.

• Route of Administration: Oral

• Course Duration:
  Treatment duration may vary from 5 to 14 days, depending on the infection type and severity.

• Instructions:

  • Swallow the tablet whole with a glass of water.

  • Can be taken with or without food, but taking it after meals helps reduce gastric irritation.

  • Do not skip doses and complete the entire course to prevent bacterial resistance.

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Safety, Warnings, and Precautions

1. Allergic Reactions:
   Avoid use in patients allergic to cephalosporins, fluoroquinolones, or penicillin.

2. Pregnancy and Lactation:
   Use with caution during pregnancy or breastfeeding under medical supervision.

3. Renal and Hepatic Impairment:
   Dose adjustments may be required for patients with kidney or liver disorders.

4. Drug Interactions:
   Inform your doctor about all medications, as fluoroquinolones may interact with antacids, NSAIDs, and other antibiotics.

5. Avoid Alcohol:
   Alcohol consumption should be avoided during therapy to minimize adverse effects.

6. Caution in Children:
   Not recommended for children under a certain age unless prescribed by a pediatric specialist.

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Possible Side Effects

Sifan-O Tablets are generally well-tolerated, but some patients may experience mild, temporary side effects such as:

• Nausea or vomiting

• Diarrhea or loose stools

• Abdominal pain or discomfort

• Dizziness or headache

• Mild skin rash

Serious side effects (rare):

• Tendon inflammation or rupture (associated with fluoroquinolones)

• Severe allergic reactions

• Clostridium difficile-associated diarrhea
  Seek immediate medical attention if any severe reactions occur.

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Storage Instructions

• Store in a cool, dry place, away from direct sunlight.

• Keep out of reach of children.

• Do not use after the expiry date mentioned on the pack.

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Why Choose Sifan-O Tablets?

Sifan-O Tablet is designed for maximum antibacterial efficacy by combining two of the most powerful antibiotics in modern medicine—Cefixime and Ofloxacin. This formulation is ideal for multi-system bacterial infections, resistant strains, and severe infections requiring aggressive therapy. The combination ensures not just infection control but also rapid recovery, reduced chances of relapse, and minimal resistance development.

Key highlights:

• Dual action against bacteria

• Fast relief from infection symptoms

• Wide-spectrum efficacy

• Clinically proven ingredients

• Convenient dosage and easy administration

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Product Specifications

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Conclusion

Sifan-O Tablet is a potent and reliable combination antibiotic therapy that ensures quick and effective treatment of a wide variety of bacterial infections. Its formulation of Cefixime 200 mg and Ofloxacin 200 mg provides a powerful double-layered defense mechanism against even the most stubborn pathogens. The convenient oral tablet format ensures patient compliance, making it suitable for outpatient use as well as hospital prescriptions.

This medication is particularly beneficial in cases where single-antibiotic therapy may not suffice, offering a comprehensive solution for respiratory, urinary, gastrointestinal, ENT, and systemic infections. With proper dosage and adherence, Sifan-O Tablets deliver fast symptom relief, minimized recurrence rates, and improved patient outcomes.